Extracellular matrix regulates smooth muscle responses to substance P.
نویسندگان
چکیده
منابع مشابه
Extracellular matrix regulates human airway smooth muscle cell migration.
Extracellular matrix proteins regulate the survival and proliferation of smooth muscle cells. Their effect on airway smooth muscle cell migration is not known. Their role in leukotriene-primed (0.1 microM leukotriene E4) chemotaxis of cultured human airway smooth muscle cells towards platelet-derived growth factor BB (1 ng.mL(-1)) was investigated. Migration of cells was greater on membranes co...
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Environmental tobacco smoke (ETS) is an environmental trigger that leads to airway inflammation and airway hyperresponsiveness (AHR) in susceptible individuals and animals, but the underlying mechanism is not fully understood. Substance P (SP) release from sensory nerve fibers has been linked to AHR. The present experiments characterize the role of SP in tracheal smooth muscle on ETS-increased ...
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The extracellular matrix (ECM) creates the microenvironment of the tissue; an altered ECM in the asthmatic airway may be central in airway inflammation and remodelling. Tumstatin is a collagen IV-derived matrikine reduced in the asthmatic airway wall that reverses airway inflammation and remodelling in small and large animal models of asthma. This study hypothesized that the mechanisms underlyi...
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Denervation of rat leg muscles caused a 2-3-fold increase in 35S-sulfate and 3H-glucosamine incorporation into proteoglycans of the muscle extracellular matrix. The size of the proteoglycans and the glycosaminoglycan chain length and degree of sulfation were unchanged. Because the rate of degradation of proteoglycans was also unchanged by denervation, we infer that denervation increases proteog...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.17.8130